From King of Prussia area: take 202 South. Take US-30 west towards Downingtown. Exit onto Lancaster US-30 business route east towards Exton. Turn right onto East Lancaster Avenue. AVE Downingtown is on your right.

From West Chester area: take 202 North, merge onto PA-100 north. Take US-30 West towards Downingtown. Exit onto Lancaster US-30 business route east towards exton. Turn right onto East Lancaster Avenue. AVE Downingtown is on your right.